Biological Activity
N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst.
Technical Data
| M. Wt | 915.73 |
| Formula | C51H42O3Pd2 |
| Storage | Store at RT |
| CAS Number | 51364-51-3 |
| PubChem ID | 9811564 |
| InChI Key | CYPYTURSJDMMMP-WVCUSYJESA-N |
| Smiles | [Pd].[Pd].O=C(C=CC1=CC=CC=C1)/C=C/C1=CC=CC=C1.O=C(C=CC1=CC=CC=C1)/C=C/C1=CC=CC=C1.O=C(C=CC1=CC=CC=C1)/C=C/C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.07 | 11 |
Preparing Stock Solutions
The following data is based on the product molecular weight 915.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.09 mL | 5.46 mL | 10.92 mL |
| 5 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 10 mM | 0.11 mL | 0.55 mL | 1.09 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Bhandarkar et al (2008) Tris(Dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo. Clin.Cancer Res. 14 5743 PMID: 18794083
Keywords: Tris DBA, supplier, N-myristoyltransferase-1, inhibitors, inhibits, antiproliferative, Transferases, TrisDBA, Other, Transferases, Post-translational, Modifications, Other, Transferases, Tocris Bioscience
