Biological Activity
Sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).
Technical Data
| M. Wt | 280.04 |
| Formula | C10H4Cl2NNaO3 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1184986-70-6 |
| PubChem ID | 44134672 |
| InChI Key | VPRPMJHKWHCUFW-UHFFFAOYSA-M |
| Smiles | [Na+].OC1=CC(=NC2=CC(Cl)=CC(Cl)=C12)C([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 28 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 280.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.57 mL | 17.85 mL | 35.71 mL |
| 5 mM | 0.71 mL | 3.57 mL | 7.14 mL |
| 10 mM | 0.36 mL | 1.79 mL | 3.57 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.71 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769
Moore et al (1990) Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor. Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I PMID:
Keywords: 5,7-Dichlorokynurenic acid sodium salt, supplier, Potent, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
