Biological Activity
A potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.
Licensing Information
Sold under license, US Patent 5,047,536
Technical Data
| M. Wt | 303.79 |
| Formula | C17H17NO2.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 158704-02-0 |
| PubChem ID | 11403931 |
| InChI Key | IJYUPBNUPIRQEP-SATBOSKTSA-N |
| Smiles | OC1=C(O)C=C(CC[C@]3([H])[C@@]([H])2C4=C(C=CC=C4)CN3)C2=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.19 | 50 | |
| water | 3.04 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 303.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.29 mL | 16.46 mL | 32.92 mL |
| 5 mM | 0.66 mL | 3.29 mL | 6.58 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.29 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Brewster et al (1990) Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. J.Med.Chem. 33 1756 PMID: 1971308
Kholi et al (1993) Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. Eur.J.Pharmacol. 235 31 PMID: 8100195
Lovenberg et al (1989) Dihydrexidine, a novel selective high potency, full dopamine D-1 receptor agonist. Eur.J.Pharmacol. 166 111 PMID: 2572425
Taylor et al (1991) Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys. Eur.J.Pharmacol. 199 389 PMID: 1680717
Keywords: Dihydrexidine hydrochloride, supplier, Selective, D1-like, agonists, Dopamine, Receptors, D5, dopaminergic, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience
