Biological Activity
Competitive nicotinic acetylcholine receptor antagonist with moderate selectivity for the neuronal α4 receptor subunit (IC50 values are 0.19 and 0.37 μM for α4β4 and α4β2 receptors respectively). Antagonizes behavioral effects of nicotine in vivo.
Technical Data
| M. Wt | 356.26 |
| Formula | C16H21NO3.HBr |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 29734-68-7 |
| PubChem ID | 11957537 |
| InChI Key | GFIGWAJEIMHJJB-LINSIKMZSA-N |
| Smiles | O=C1CC2=C(CCN4[C@]32C(CC4)=CC[C@H](OC)C3)CO1.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.91 | 25 | |
| water | 35.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 356.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.03 mL | 28.07 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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References
References are publications that support the products' biological activity.
Williams and Robinson (1984) Binding of the nicotinic cholinergic antagonist, dihydro-β-erythroidine, to rat brain tissue. J.Neurosci. 4 2906 PMID: 6502210
Damaj et al (1995) In vivo pharmacological effects of dihydro-β-erythroidine, a nicotinic antagonist, in mice. Psychopharmacology 117 67 PMID: 7724704
Harvey et al (1996) Multiple determinants of dihydro-β-erythroidine sensitivity on rat neuronal nicotinic receptor #945; subunits. J.Neurochem. 67 1953 PMID: 8863500
Keywords: Dihydro-b-erythroidine hydrobromide, supplier, antagonists, neuronal, alpha4-containing, nicotinic, receptors, α4β2, a4b2, Nicotinic, Receptors, Acetylcholine, nAChR, Non-Selective, Subtypes, Other, Dihydro-beta-erythroidine, hydrobromide, Dihydro-β-erythroidine, hydrobromide, DHβE, DHbE, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, (a4b2), Receptors, Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience
