Biological Activity
Partial α-adrenergic agonist. Partial D2 dopaminergic receptor agonist. Competitive 5-HT antagonist.
Compound Libraries
Dihydroergotamine mesylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 679.79 |
| Formula | C33H37N5O5.CH3SO3H |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 6190-39-2 |
| PubChem ID | 71171 |
| InChI Key | ADYPXRFPBQGGAH-UMYZUSPBSA-N |
| Smiles | CS(=O)(O)=O.[H][C@]4([C@@]([H])3C[C@@H]([C@@](N[C@@]5(C)C(N([C@@]([H])(CC8=CC=CC=C8)C(N7[C@]([H])6CCC7)=O)[C@@]6(O)O5)=O)=O)CN4C)CC1=CNC2=C1C3=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 67.97 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 679.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.47 mL | 7.36 mL | 14.71 mL |
| 5 mM | 0.29 mL | 1.47 mL | 2.94 mL |
| 10 mM | 0.15 mL | 0.74 mL | 1.47 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.29 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
de Boer et al (1991) Carotid vascular effects of ergotamine and dihydroergotamine in the pig: no exclusive mediation via 5-HT1-like receptors. Br.J.Pharmacol. 104 183 PMID: 1664762
Doggrell et al (1992) Further analysis of the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the responses of the rat aorta to 5-hydroxytryptamine. J.Auton.Pharmacol. 12 223 PMID: 1512277
Lesage et al (1998) Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br.J.Pharmacol. 123 1655 PMID: 9605573
Villalon et al (1992) Effects of S9977 and dihydroergotamine in an animal experimental model for migraine. Pharmacol.Res. 25 125 PMID: 1635891
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