Biological Activity
Constituent of various spider toxins. Reported to be specific blocker of glutamate receptors.
Technical Data
| M. Wt | 282.25 |
| Formula | C12H14N2O6 |
| Storage | Desiccate at -20°C |
| CAS Number | 111872-98-1 |
| PubChem ID | 3082629 |
| InChI Key | XWUFTPIDMLSXES-QMMMGPOBSA-N |
| Smiles | OC1=CC=C(CC(N[C@@]([H])(CC(N)=O)C(O)=O)=O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 50 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 282.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.71 mL | 35.43 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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References
References are publications that support the products' biological activity.
Pan-Hou et al (1987) Inhibitory effect of 2,4-dihydroxyphenylacetylasparagine, a common moiety of spider toxin, on glutamate binding to rat brain synaptic membranes. Neurosci.Lett. 81 199 PMID: 2827066
Pan-Hou et al (1989) A spider toxin (JSTX) inhibits L-glutamate uptake by rat brain synaptosomes. Brain Res. 476 354 PMID: 2564797
Usherwood et al (1990) Mechanisms of neurotoxicity of low molecular weight spider toxins. Basic Science in Toxicology. Ed. G.N. Volans 569 PMID:
Keywords: 2,4-Dihydroxyphenylacetyl-L-asparagine, supplier, Component, Joro, spider, toxin, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, antagonists, blockers, Miscellaneous, Glutamate, Miscellaneous, Glutamate, Tocris Bioscience
