BiologicalActivity
Non-selectiveantihistaminethatdisplayscognitiveenhancingABIlities.Alsodisplayshighaffinityfor5-HT(particularly5-HT6and5-HT7),α-adrenergic,dopaminergic,AMPAandNMDAreceptors,andL-typecalciumchannels.Doesnotinhibitacetylcholinesteraseactivity.ExhibitsneuroprotectiveactivityincellularmodelsofAlzheimer'sandHuntington'sdiseaseandpreservescognitivefunctionfollowingadmiNISTrationtoAF64Alesionedrats.Protectsneuronsagainsttheneurotoxicactionofβ-amyloidfragment;showntoenhanceautophagyinyeastandreduceintracellularAβ42levels.
CompoundLibraries
DimebondihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 392.37 |
| Formula | C21H25N3.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98% |
| CASNumber | 97657-92-6 |
| PubChemID | 23729232 |
| InChIKey | GTWLIQOLGOZTLF-UHFFFAOYSA-N |
| Smiles | CC(N=C4)=CC=C4CCN2C1=CC=C(C)C=C1C3=C2CCN(C)C3.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.24 | 100 | |
| ethanol | 9.81 | 25 | |
| water | 39.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight392.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.55mL | 12.74mL | 25.49mL |
| 5mM | 0.51mL | 2.55mL | 5.1mL |
| 10mM | 0.25mL | 1.27mL | 2.55mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
