Biological Activity
Inhibitor of aldehyde dehydrogenase that displays antialcoholism activity. Shown to reversibly stimulate Ca2+-ATPase activity and inhibit V-ATPase (EC50 = 26 μM). Also inhibits expression of MMP-2 and MMP-9 and displays anti-invasive activity.
Technical Data
| M. Wt | 296.54 |
| Formula | C10H20N2S4 |
| Storage | Store at +4°C |
| CAS Number | 97-77-8 |
| PubChem ID | 3117 |
| InChI Key | AUZONCFQVSMFAP-UHFFFAOYSA-N |
| Smiles | S=C(SSC(N(CC)CC)=S)N(CC)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.93 | 20 | |
| ethanol | 29.65 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 296.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.86 mL | 33.72 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.74 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Starling et al (1996) Stimulation of the Ca2+-ATPase of sarcoplasmic reticulum by disulfiram. Biochem.J. 320 101 PMID: 8947473
Cho et al (2007) Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J.Biochem.Mol.Biol. 40 1069 PMID: 18047805
Johnson et al (2009) Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Anal.Biochem. 398 203 PMID: 20018164
Fisher et al (2010) The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo. J.Pharmacol.Exp.Ther. 332 326 PMID: 19820208
Keywords: Disulfiram, supplier, aldehyde, dehydrogenase, inhibitors, inhibits, anti-alcoholism, stimulates, stimulators, reversible, ca2+-atpase, V-atpase, vacuolar, atpase, MMP, matrix, metalloproteinase, metalloprotease, MMP-2, MMP-9, proteinase, protease, Tetraethylthiuram, disulfide, Aldehyde, Dehydrogenase, Ca2+-ATPase, H+-ATPase, Matrix, Metalloprotease, Ca2+-ATPase, Tocris Bioscience
