Biological Activity
β1- and β2-adrenoceptor agonist with some action at the α1-adrenoceptor.
Compound Libraries
Dobutamine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 337.85 |
| Formula | C18H23NO3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 49745-95-1 |
| PubChem ID | 65324 |
| InChI Key | BQKADKWNRWCIJL-UHFFFAOYSA-N |
| Smiles | Cl.CC(CCC1=CC=C(O)C=C1)NCCC1=CC=C(O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.78 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 337.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.96 mL | 14.8 mL | 29.6 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.92 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.96 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Brown et al (1987) Dobutamine: positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardium. Naunyn Schmiedebergs Arch.Pharmacol. 335 385 PMID: 3600817
Deighton et al (1992) Characterization of the beta adrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atrium. J.Pharmacol.Exp.Ther. 262 532 PMID: 1354251
Merck Index 12 3456 PMID:
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