Biological Activity
Peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).
Technical Data
| M. Wt | 425.92 |
| Formula | C22H24ClN5O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 57808-66-9 |
| PubChem ID | 3151 |
| InChI Key | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)NC2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 2.13 | 5 | |
| DMSO | 42.59 | 100 | |
| ethanol | 2.13 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 425.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.74 mL | 23.48 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Neimegeers et al (1980) The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int.Pharmacodyn.Ther. 244 130 PMID: 7416883
Prakash and Wagstaff (1998) Domperidone. A review of its use in diabetic gastropathy. Drugs 56 429 PMID: 9777316
Osinski et al (2005) Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 81 211 PMID: 15894081
Keywords: Domperidone, supplier, Peripheral, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, R33812, R, 33812, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience
