Biological Activity
Brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.
Technical Data
| M. Wt | 439.94 |
| Formula | C23H25N5O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 170911-68-9 |
| PubChem ID | 197705 |
| InChI Key | ZXENQGQAPOYDOJ-UHFFFAOYSA-N |
| Smiles | NCCC2=CNC1=CC=C(OCC(N3CCN(C4=CC=C(C#N)C=C4)CC3)=O)C=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 439.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.37 mL | 22.73 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.55 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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References
References are publications that support the products' biological activity.
Letienne et al (2003) Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J.Pharmacol.Exp.Ther. 305 749 PMID: 12606602
Letienne et al (2005) Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J.Pharmacol.Exp.Ther. 315 849 PMID: 16027226
Munoz-Islas et al (2006) Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors. Br.J.Pharmacol. 149 82 PMID: 16880765
Keywords: Donitriptan hydrochloride, supplier, serotonin, 5-HT1B, 5-HT1D, 5-HT1B/1D, receptors, agonists, 5-HT1B, Receptors, 5-HT1D, Receptors, 5-HT1B, Receptors, Tocris Bioscience
