Biological Activity
D2 receptor antagonist. Also exhibits affinity for 5-HT, α-adrenergic and histamine receptors,and hERG channels. Antipsychotic and antiemetic.
Technical Data
| M. Wt | 379.43 |
| Formula | C22H22FN3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 548-73-2 |
| PubChem ID | 3168 |
| InChI Key | RMEDXOLNCUSCGS-UHFFFAOYSA-N |
| Smiles | FC1=CC=C(C(CCCN2CCC(N3C(NC4=C3C=CC=C4)=O)=CC2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.94 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 379.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.64 mL | 13.18 mL | 26.36 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.27 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.64 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Peroutka and Synder (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. Am.J.Psychiatry 137 1518 PMID: 6108081
Rajamani et al (2005) A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorg.Med.Chem.Lett. 15 1737 PMID: 15745831
Keywords: Droperidol, supplier, dopamine, receptors, D2, antagonists, antipsychotics, antiemetics, herg, channels, D2, Receptors, Voltage-Gated, Potassium, Channels, D2, Receptors, Tocris Bioscience
