Biological Activity
Dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).
Compound Libraries
Dynole 34-2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 408.58 |
| Formula | C25H36N4O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1128165-88-7 |
| PubChem ID | 44157463 |
| InChI Key | MYIMRONQBLZJFI-DYTRJAOYSA-N |
| Smiles | CN(C)CCCN2C1=CC=CC=C1C(/C=C(C(NCCCCCCCC)=O)C#N)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.86 | 100 | |
| ethanol | 20.43 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 408.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.24 mL | 24.48 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Hill et al (2009) Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 52 3762 PMID: 19459681
Hill et al (2010) Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 53 4094 PMID: 20426422
Keywords: Dynole 34-2, supplier, dynamin, I, inhibitors, inhibits, gtpases, rme, receptor-mediated, endocytosis, GTPase, GTPase, Tocris Bioscience
