Biological Activity
Endogenous kappa receptor agonist.
Technical Data
| M. Wt | 2147.51 |
| Formula | C99H155N31O23 |
| Sequence | YGGFLRRIRPKLKWDNQ |
| Storage | Desiccate at -20°C |
| CAS Number | 80448-90-4 |
| PubChem ID | 16133805 |
| InChI Key | JMNJYGMAUMANNW-FIXZTSJVSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.80 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2147.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 5 mM | 0.09 mL | 0.47 mL | 0.93 mL |
| 10 mM | 0.05 mL | 0.23 mL | 0.47 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.09 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dhawan et al (1996) International union of pharmacology XII. Classification of opioid receptors. Pharmacol.Rev. 48 567 PMID: 8981566
Tan-No et al (2008) Cysteine protease inhibitors suppress the development of tolerance to morphine antinociception. Neuropeptides 42 239 PMID: 18440066
Keywords: Dynorphin A, supplier, Endogenous, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, DynorphinA, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
