Biological Activity
Synthetic analogue of all trans-retinoic acid. Promotes differentiation of human embryonal carcinoma (EC) cells primarily into epithelial-like cells, along with a small number of neurons.
Technical Data
| M. Wt | 332.44 |
| Formula | C23H24O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1010694-08-2 |
| PubChem ID | 25111943 |
| InChI Key | PMRFEKRJNZQOSY-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=CC(C#CC3=CC(C(O)=O)=CC=C3)=C2)C(C)(C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 16.62 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 332.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497 PMID: 19082150
Clemens et al (2013) The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy. Mol.Biosyst. 9 677 PMID: 23364809
Keywords: EC 19, supplier, EC19, synthetic, all-trans, retinoic, acid, receptors, ATRA, differentiation, stem, cells, retinoids, Retinoic, Acid, Receptors, Retinal, Stem, Cells, Retinoic, Acid, Receptors, Tocris Bioscience
