Biological Activity
Photostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells.
Licensing Information
Sold under license from Reinnervate Limited, patent pending
Compound Libraries
EC 23 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 332.44 |
| Formula | C23H24O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 104561-41-3 |
| PubChem ID | 10314719 |
| InChI Key | OQVLOWLEEHYBJH-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=CC(C#CC3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.24 | 100 | |
| ethanol | 3.32 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 332.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.04 mL | 30.08 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.5 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497 PMID: 19082150
Barnard et al (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15 11430 PMID: 19821467
Maltman et al (2009) Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol.Biosyst. 5 458 PMID: 19381361
Keywords: EC 23, supplier, retinoids, synthetic, stem, cells, induces, differentiation, ATRA, retinoic, acid, receptors, agonists, EC23, Retinoic, Acid, Receptors, Retinal, Stem, Cells, ESCs, and, iPSC, Retinoic, Acid, Receptors, Tocris Bioscience
