BiologicalActivity
β-secretaseinhibitor(IC50=1.6μM);inhibitsamyloidassembly.InhibitstheformationofamyloidfibrilsbyproteinssuchasAβ,α-synucleinandhuntingtin.ReducesAβ42-inducedcelldeathinthreedifferentcelltypes.Alsoinhibitsglutamatedehydrogenase.InhibitscellgrowthandselectivelyinducesapoptosisinA431andhumanpancreaticcancercells.AlsoaDNMT1inhibitor.
CompoundLibraries
EGCGisalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 458.37 |
| Formula | C22H18O11 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 989-51-5 |
| PubChemID | 65064 |
| InChIKey | WMBWREPUVVBILR-WIYYLYMNSA-N |
| Smiles | O=C(C4=CC(O)=C(O)C(O)=C4)O[C@@H]2CC1=C(O)C=C(O)C=C1O[C@@H]2[C@]3=CC(O)=C(O)C(O)=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.92 | 50 | |
| ethanol | 45.84 | 100 | |
| water | 4.58 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight458.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.18mL | 10.91mL | 21.82mL |
| 5mM | 0.44mL | 2.18mL | 4.36mL |
| 10mM | 0.22mL | 1.09mL | 2.18mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
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ProductDatasheets
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