Biological Activity
Selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Also available as part of the Group II mGlu Receptor Tocriset™.
Technical Data
| M. Wt | 175.18 |
| Formula | C7H13NO4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 170984-72-2 |
| PubChem ID | 5311079 |
| InChI Key | QFYBYZLHPIALCZ-ZETCQYMHSA-N |
| Smiles | N[C@](CCC(O)=O)(CC)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 175.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.71 mL | 28.54 mL | 57.08 mL |
| 5 mM | 1.14 mL | 5.71 mL | 11.42 mL |
| 10 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 50 mM | 0.11 mL | 0.57 mL | 1.14 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jane et al (1996) Potent antagonists at L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate recpetors in neonatal rat spinal cord. Neuropharmacology 35 1029 PMID: 9121605
Thomas et al (1996) (S)-α-Ethylglutamic acid and (RS)-α-cyclopropyl-4-phosphonophenylglycine as antagonists of L-AP4- and (1S,3S)-ACPD-induced depression of monosynaptic excitation of neonatal rat motoneurones. Br.J.Pharmacol. 117 70P PMID:
Keywords: EGLU, supplier, selective, group, II, mGlur, antagonist, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
