Biological Activity
Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.
Technical Data
| M. Wt | 380.35 |
| Formula | C14H24N2O10 |
| Storage | Store at RT |
| CAS Number | 67-42-5 |
| PubChem ID | 6207 |
| InChI Key | DEFVIWRASFVYLL-UHFFFAOYSA-N |
| Smiles | O=C(CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1M NaOH | 38.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 380.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.15 mL | 26.29 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Boullerne et al (2001) Role of calcium in nitric oxide-induced cytotoxicity: EGTA protects mouse oligodendrocytes. J.Neurosci.Res. 63 124 PMID: 11169622
Fisher et al (2004) Catalytic superoxide scavenging by metal complexes of the calcium chelator EGTA and contrast agent EHPG. Biochem.Biophy.Res.Comms. 323 163 PMID:
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