Biological Activity
Potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).
Compound Libraries
EMD 386088 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 283.2 |
| Formula | C14H15N2Cl.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1171123-46-8 |
| PubChem ID | 56972198 |
| InChI Key | WWSNDUWIZDYGIQ-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(C2=CC(Cl)=CC=C2N1)C1=CCNCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.32 | 100 | |
| water | 7.08 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 283.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.66 mL | 35.31 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Mattsson et al (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg.Med.Chem.Lett. 15 4230 PMID: 16055331
Keywords: EMD 386088 hydrochloride, supplier, Potent, 5-HT6, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, EMD386088, hydrochloride, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience
