Biological Activity
Selective 5-HT6 agonist (with a Ki value of 16 nM at human 5-HT6 receptors). Exhibits potency comparable to serotonin for the activation of adenylate cyclase. Displays antidepressant-like effects.
Technical Data
| M. Wt | 336.38 |
| Formula | C15H22N2O.C2H2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 263744-72-5 |
| PubChem ID | 90488919 |
| InChI Key | IFGWAHGHGDZBEH-UHFFFAOYSA-N |
| Smiles | CCC2=C(CCN(C)C)C1=CC(OC)=CC=C1N2.O=C(C(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.64 | 100 | |
| water | 16.82 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 336.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.86 mL | 29.73 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Glennon et al (2000) 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Svenningsson et al (2007) Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J.Neurosci. 27 4201 PMID: 17428998
Keywords: EMDT oxalate, supplier, EMDT, oxalate, 5ht6, 5-HT6, agonist, agonists, serotonin-6, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience
