Biological Activity
Reversible and non-competitive CBP/p300 inhibitor (IC50 values are 1.1 and 2.9 μM, respectively). Cell permeable.
Technical Data
| M. Wt | 440.49 |
| Formula | C27H24N2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1675821-32-5 |
| PubChem ID | 91826273 |
| InChI Key | LUGQBJDYUPNAQQ-UHFFFAOYSA-N |
| Smiles | CC1=C(/C=C2C(N(CC3=CC=CC=C3)C(N(CC4=CC=CC=C4)C2=O)=O)=O)C(C)=CC(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.05 | 100 | |
| ethanol | 8.81 | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 440.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Milite et al (2015) A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J.Med.Chem. 58 2779 PMID: 25730130
Keywords: EML 425, supplier, EML425, CBP, CREB, proteins, histone, lysine, acetyltransferases, inhibits, inhibitors, HAT, KAT, reversible, non-competitive, Histone, Acetyltransferases, Post-translational, Modifications, Histone, Acetyltransferases, Tocris Bioscience
