BiologicalActivity
Selectiveinhibitorofp38αandp38β2thatdisplaysnoactivityatp38γ,p38δ,ERK1/2andJNK1.InhibitsproductionofinflammatorycytokinesincludingIL-8,TNF-α,IL-6,IL-1βandIL-10(IC50valuesare4,5,17,30and74nMrespectively).Displaysanti-inflammatoryactivityinmurinemodelsofacuteandchronicdermatitis.
CompoundLibraries
EO1428isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 415.71 |
| Formula | C20H16BrClN2O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 321351-00-2 |
| PubChemID | 9801969 |
| InChIKey | HDCLCHNAEZNGNV-UHFFFAOYSA-N |
| Smiles | CC1=CC=CC=C1C(C2=CC=C(NC3=C(N)C=C(Br)C=C3)C=C2Cl)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.57 | 100 | |
| ethanol | 20.79 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight415.71.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.41mL | 12.03mL | 24.06mL |
| 5mM | 0.48mL | 2.41mL | 4.81mL |
| 10mM | 0.24mL | 1.2mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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ProductDatasheets
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