BiologicalActivity
PotentandselectiveERK5inhibitor;inhibitsEGFR-inducedERK5autophosphorylation(EC50=90nM)andERK5enzymaticactivity(IC50=162nM).Exhibitsatleast30-foldselectivityforERK5overLRRK2inacellbasedassay.AlsoselectiveforERK5overapanelofotherkinases.Orallybioavailable.
LicensingInformation
SoldunderlicensefromDana-FarberCancerInstitute.
CompoundLibraries
ERK5-IN-1isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 638.8 |
| Formula | C36H46N8O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1435488-37-1 |
| PubChemID | 71604307 |
| InChIKey | XVBGRTMNFNMINE-UHFFFAOYSA-N |
| Smiles | O=C2N(C)C3=C(N=C(NC5=CC=C(C(N6CCC(N7CCN(C)CC7)CC6)=O)C=C5OCC)N=C3)N(C4CCCC4)C1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 63.88 | 100 | |
| ethanol | 63.88 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight638.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.57mL | 7.83mL | 15.65mL |
| 5mM | 0.31mL | 1.57mL | 3.13mL |
| 10mM | 0.16mL | 0.78mL | 1.57mL |
| 50mM | 0.03mL | 0.16mL | 0.31mL |
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