Tocris/ETP 45658/4702/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/ETP 45658/4702/10/10 mg

Tocris/ETP 45658/4702/10/10 mg

商品编号： 4702/10

品牌： Tocris Bioscience

市场价： ¥3900.00

美元价： 2340.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentPI3-kinaseinhibitor;alsoinhibitsDNA-PKandmTOR

ChemicalName:3-[1-Methyl-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylphenol

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PI3-kinaseinhibitor(IC₅₀valuesare22,30,129and710nMforPI3-Kα,PI3-Kδ,PI3-KβandPI3-Kγrespectively).AlsoinhibitsDNA-PKandmTOR(IC₅₀valuesare70.6and152nMrespectively).InhibitsproliferationofmultiplecancercelllinesinvitroandreducesAktphosphorylationlevelsinvivo.

CompoundLibraries

ETP45658isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	311.34
Formula	C₁₆H₁₇N₅O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1198357-79-7
PubChemID	25229608
InChIKey	BJVRNXSHJLDZJR-UHFFFAOYSA-N
Smiles	CN2C1=NC(C3=CC(O)=CC=C3)=NC(N4CCOCC4)=C1C=N2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	31.13	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight311.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.21mL	16.06mL	32.12mL
5mM	0.64mL	3.21mL	6.42mL
10mM	0.32mL	1.61mL	3.21mL
50mM	0.06mL	0.32mL	0.64mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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