Biological Activity
Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein kinases, including those upstream of Mnk1/2.
Technical Data
| M. Wt | 301.21 |
| Formula | C13H16N4.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| PubChem ID | 71755761 |
| InChI Key | ASYCTHXAPLLLSZ-UHFFFAOYSA-N |
| Smiles | C1(C2=CC(C3=CC=NC=C3)=NN2)CCNCC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 301.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.32 mL | 16.6 mL | 33.2 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Oyarzabal et al (2010) Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J.Med.Chem. 53 6618 PMID: 20722422
Keywords: ETP 45835 dihydrochloride, supplier, ETP45835, dihydrochloride, mitogen-activated, protein, kinase-interacting, kinase, Mnk1, Mnk2, inhibitors, inhibits, [791852-46-5], Mnk, Mnk, Tocris Bioscience
