Biological Activity
Potent and selective noncompetitive AT1 receptor antagonist (IC50 = 37 nM). Reduces blood pressure in a rat model. Active metabolite of losartan potassium (Cat.No. 3798).
Technical Data
| M. Wt | 436.89 |
| Formula | C22H21ClN6O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 124750-92-1 |
| PubChem ID | 108185 |
| InChI Key | ZEUXAIYYDDCIRX-UHFFFAOYSA-N |
| Smiles | CCCCC1=NC(Cl)=C(C(O)=O)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.69 | 100 | |
| ethanol | 43.69 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 436.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.44 mL | 22.89 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wong et al (1990) Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent. J.Pharmacol.Exp.Ther. 255 211 PMID: 2213556
Keywords: EXP 3174, supplier, EXP3194, losartan, carboxylic, acid, metabolite, hypertension, antihypertensive, AT1, antagonists, antagonism, angiotensin, II, potent, noncompetitive, selective, Angiotensin, AT1, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience
