Tocris/Echinomycin/5520/1/1 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Echinomycin/5520/1/1 mg

Tocris/Echinomycin/5520/1/1 mg

商品编号： 5520/1

品牌： Tocris Bioscience

市场价： ¥2100.00

美元价： 1260.00

产地：美国(厂家直采)

公司：

产品分类：转录表达

公司分类： Target_Expression

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:HighlypotentandselectiveHIF-1αinhibitor

AlternativeNames:QuinomycinA

ChemicalName:N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic(37)-thioether

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighlypotentandselectiveHIF-1αinhibitor(IC₅₀=29.4pM).SelectivelyinhibitsHIF-1bindingtotheVEGFpromoterwithoutaffectingthebindingofAP-1orNF-κB.Inhibitscolonyformationofcancerstemcells(CSC)witha100-foldselectivityovernormalhematopoieticProgenitorcells.ErADIcatesmouselymphomasandhumanAMLxenograftsbyeliminatingCSCs.

TechnicalData

M.Wt	1101.26
Formula	C₅₁H₆₄N₁₂O₁₂S₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	512-64-1
PubChemID	91826096
InChIKey	AUJXLBOHYWTPFV-LDUXBRJQSA-N
Smiles	O=C(N[C@](C(N[C@H](C(N(C)[C@@](C(SC[C@@](N(C)C([C@H](C)NC4=O)=O)([H])C3=O)SC)([H])C(N(C)[C@@H]([C@@H](C)C)C(OC[C@]([H])4NC(C5=CN=C(C=CC=C6)C6=N5)=O)=O)=O)=O)C)=O)([H])COC([C@H]([C@@H](C)C)N3C)=O)C2=NC1=CC=CC=C1N=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	5.51	5

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1101.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.91mL	4.54mL	9.08mL
5mM	0.18mL	0.91mL	1.82mL
10mM	0.09mL	0.45mL	0.91mL
50mM	0.02mL	0.09mL	0.18mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

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