Tocris/Eeyarestatin I/3922/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Eeyarestatin I/3922/10/10 mg

Tocris/Eeyarestatin I/3922/10/10 mg

商品编号： 3922/10

品牌： Tocris Bioscience

市场价： ¥4100.00

美元价： 2460.00

产地：美国(厂家直采)

公司：

产品分类：细胞凋亡

公司分类： Apoptosis

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentinhibitorofER-associatedproteindegradationandtranslocation

ChemicalName:3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofendoplasmicreticulumassociatedproteindegradation(ERAD).Specificallytargetsthep97-associateddeubiquinatingprocess(PAD)andinhibitsataxin-3(atx3)-dependentdeubiquitination.AlsoinhibitsSec61-mediatedproteintranslocationattheER.Displayscytotoxicactivitypreferentiallyagainstcancercells;inducescelldeathviatheproapoptoticproteinNOXA.

TechnicalData

M.Wt	630.44
Formula	C₂₇H₂₅Cl₂N₇O₇
Storage	Desiccateat+4°C
Purity	≥98%(HPLC)
CASNumber	412960-54-4
PubChemID	23947580
InChIKey	JTUXTPWYZXWOIB-LWWHHIEBSA-N
Smiles	O=C1N(C2=CC=C(Cl)C=C2)C(N(O)C(NC4=CC=C(Cl)C=C4)=O)C(C)(C)N1CC(N/N=C/C=C/C3=CC=C([N+]([O-])=O)O3)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	63.04	100
	ethanol	3.15	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight630.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.59mL	7.93mL	15.86mL
5mM	0.32mL	1.59mL	3.17mL
10mM	0.16mL	0.79mL	1.59mL
50mM	0.03mL	0.16mL	0.32mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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