BiologicalActivity
SelectiveblockerofL-typeandT-typeCa2+channels.DisplaysminimalinhibitionofN-andP/Q-typechannelsandnoinhibitionofR-typechannels.R(-)andS(+)-enantiomersdisplaydifferentchannelselectivity;S(+)-EfonidipineblocksL-typeandT-typechannelswhereasR(-)-EfonidipinedisplaysselectivityforT-typechannels.Exhibitsantihypertensiveactivity.
CompoundLibraries
EfonidipinehydrochloridemonoethanolateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 714.18 |
| Formula | C34H38N3O7P.HCl.C2H5OH |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 111011-76-8 |
| PubChemID | 163838 |
| InChIKey | IKBJGZQVVVXCEQ-UHFFFAOYSA-N |
| Smiles | CC1=C(P4(OCC(C)(C)CO4)=O)C(C3=CC([N+]([O-])=O)=CC=C3)C(C(OCCN(CC5=CC=CC=C5)C2=CC=CC=C2)=O)=C(C)N1.CCO.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 71.42 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight714.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.4mL | 7mL | 14mL |
| 5mM | 0.28mL | 1.4mL | 2.8mL |
| 10mM | 0.14mL | 0.7mL | 1.4mL |
| 50mM | 0.03mL | 0.14mL | 0.28mL |
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ProductDatasheets
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