Tocris/Eggmanone/5695/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/Eggmanone/5695/10/10 mg

Tocris/Eggmanone/5695/10/10 mg

商品编号： 5695/10

品牌： Tocris Bioscience

市场价： ¥3100.00

美元价： 1860.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectivePDE4inhibitor;suppresseshedgehogsignaling

ChemicalName:5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivephosphodiesterase(PDE)4inhibitor(IC₅₀=72nM).Exhibits>40-foldselectivityoverPDE3,PDE10,andPDE11.Displaysnosignificantactivityonapanelof442kinases,158GPCRsand21phosphatases.SuppresseshedgehogsignalingthroughPDEantagonism,downstreamofsmoothenedsignaling.ReducestranscriptionofGli1andPtc1.

TechnicalData

M.Wt	416.58
Formula	C₂₀H₂₀N₂O₂S₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	505068-32-6
PubChemID	1158635
InChIKey	XAKJIQPEGSCYIP-UHFFFAOYSA-N
Smiles	CC(CN1C(C2=C(N=C1SCC(C3=CC=CS3)=O)SC4=C2CCCC4)=O)=C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	8.33	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight416.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.4mL	12mL	24mL
5mM	0.48mL	2.4mL	4.8mL
10mM	0.24mL	1.2mL	2.4mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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