Biological Activity
Potent natural tachykinin receptor ligand (pD2 values are 9.21, 8.22 and 7.11 for guinea pig NK1, rabbit NK2 and rat NK3 receptors respectively).
Technical Data
| M. Wt | 1188.4 |
| Formula | C54H85N13O15S |
| Sequence |
XPSKDAFIGLM (Modifications: X = Glp, Met-11 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 69-25-0 |
| PubChem ID | 10328936 |
| InChI Key | AYLPVIWBPZMVSH-FCKMLYJASA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.20 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1188.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.84 mL | 4.21 mL | 8.41 mL |
| 5 mM | 0.17 mL | 0.84 mL | 1.68 mL |
| 10 mM | 0.08 mL | 0.42 mL | 0.84 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.17 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Regoli et al (1989) Receptors for substance P and related neurokinins. Pharmacology 38 1 PMID: 2542998
Severini et al (2002) The tachykinin peptide family. Pharmacol.Rev. 54 285 PMID: 12037144
Sturmer et al (1964) Synthetic peptides related to eledoisin. Experientia 20 303 PMID: 5855848
Keywords: Eledoisin, supplier, Potent, tachykinin, receptor, ligands, Tachykinin, Non-Selective, Neurokinin, Receptors, Other, Tachykinin, Other, Tachykinin, Tocris Bioscience
