Biological Activity
Orally active, selective 5-HT1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo. Displays antimigraine activity.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries
Eletriptan hydrobromide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 463.43 |
| Formula | C22H26N2O2S.HBr |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 177834-92-3 |
| PubChem ID | 656631 |
| InChI Key | UTINOWOSWSPFLJ-FSRHSHDFSA-N |
| Smiles | CN1[C@@H](CC3=CNC2=CC=C(CCS(=O)(C4=CC=CC=C4)=O)C=C23)CCC1.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.34 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 463.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.79 mL | 21.58 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Napier et al (1999) Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]-eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur.J.Pharmacol. 368 259 PMID: 10193663
Gupta et al (2000) The in vivo pharmacological profile of eletriptan (UK-116,044): a potent and novel 5-HT(1B/1D) receptor agonist. Eur.J.Pharmacol. 398 73 PMID: 10856450
Willems et al (1998) Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn-Schmied.Arch.Pharmacol. 358 212 PMID:
Keywords: Eletriptan hydrobromide, supplier, 5-HT1B, 5-HT1D, 5-HT1B/1D, selective, orally, active, agonists, receptors, serotonin, Pfizer, 5-HT1B, Receptors, 5-HT1D, Receptors, 5-HT1B, Receptors, Tocris Bioscience
