![Tocris/[Ala1,3,11,15]-Endothelin/1197/500U/500 ug](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).
Technical Data
| M. Wt | 2368 |
| Formula | C109H163N25O32S |
| Sequence | ASASSLMDKEAVYFAHLDIIW |
| Storage | Desiccate at -20°C |
| CAS Number | 121204-87-3 |
| PubChem ID | 16143287 |
| InChI Key | NRTWVLDGYXCWHD-IGKRDWOESA-N |
| Smiles | [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2368. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 5 mM | 0.08 mL | 0.42 mL | 0.84 mL |
| 10 mM | 0.04 mL | 0.21 mL | 0.42 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.08 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Nakamichi et al (1992) Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET1. Biochem.Biophys.Res.Commun. 182 144 PMID: 1310013
Panek et al (1992) Endothelin and structurally related analogs distinguish between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 183 566 PMID: 1312833
Keywords: [Ala1,3,11,15]-Endothelin, supplier, Selective, ETB, agonists, Receptors, Endothelin, Endothelin, ETB, Receptors, Endothelin, ETB, Receptors, Tocris Bioscience
