![Tocris/[Leu5]-Enkephalin/1889/25/25 mg](https://www.ebiomall.cn/images/201712/1512586227401806107.jpg)
Biological Activity
Endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC50 = 11.4 nM). Short-acting in vivo.
Technical Data
| M. Wt | 555.63 |
| Formula | C28H37N5O7 |
| Sequence | YGGFL |
| Storage | Desiccate at -20°C |
| CAS Number | 58822-25-6 |
| PubChem ID | 461776 |
| InChI Key | URLZCHNOLZSCCA-VABKMULXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 555.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.8 mL | 9 mL | 18 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.8 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
DiMaio et al (1982) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432 PMID: 6296388
Law and Loh (1978) 3H-Leu5-enkephalin specific binding to synaptic membrane - comparison with 3H-dihydromorphine and 3H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409 PMID: 705021
Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209 PMID: 862920
Keywords: [Leu5]-Enkephalin, supplier, Endogenous, opioids, agonists, peptide, Receptors, ICI114740, enkephalin, ICI, 114740, Dynorphin-(1-5), YGGFL, Miscellaneous/Non-selective, Opioids, Miscellaneous/Non-selective, Opioids, Tocris Bioscience
