Biological Activity
High affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.
Licensing Information
Sold under license from the NIH, US Patent 5,314,899
Technical Data
| M. Wt | 208.69 |
| Formula | C11H13ClN2 |
| Storage | Desiccate at +4°C |
| CAS Number | 148152-66-3 |
| PubChem ID | 1204 |
| InChI Key | NLPRAJRHRHZCQQ-UHFFFAOYSA-N |
| Smiles | ClC(N=C3)=CC=C3C2C1CCC(C2)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.55 | 100 | |
| ethanol | 24.55 | 100 | |
| water | 1.23 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 208.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.79 mL | 23.96 mL | 47.92 mL |
| 5 mM | 0.96 mL | 4.79 mL | 9.58 mL |
| 10 mM | 0.48 mL | 2.4 mL | 4.79 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.96 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563 PMID: 8183234
Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774 PMID: 7476906
Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377 PMID: 9536034
Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783 PMID: 10751429
Spande et al (1992) Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc. 114 3475 PMID:
Keywords: (±)-Epibatidine, supplier, potent, nicotinic, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, nAChR, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
