Biological Activity
Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.
Technical Data
| M. Wt | 414.5 |
| Formula | C24H30O6 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 107724-20-9 |
| PubChem ID | 443872 |
| InChI Key | JUKPWJGBANNWMW-VWBFHTRKSA-N |
| Smiles | O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.14 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 414.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.06 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650 PMID: 2949071
McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190 PMID: 11714095
Keywords: Eplerenone, supplier, Selective, mineralocorticoid, receptor, antagonists, Aldosterone, Receptors, Inspra, Epoxymexrenone, Mineralocorticoid, Receptor, Mineralocorticoid, Receptor, Tocris Bioscience
