Biological Activity
General anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.
Technical Data
| M. Wt | 244.29 |
| Formula | C14H16N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 33125-97-2 |
| PubChem ID | 667484 |
| InChI Key | NPUKDXXFDDZOKR-LLVKDONJSA-N |
| Smiles | O=C(OCC)C1=CN=CN1[C@@H]([C@@]2=CC=CC=C2)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 12.21 | 50 | |
| ethanol | 24.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 244.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.47 mL | 40.93 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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References
References are publications that support the products' biological activity.
Belelli et al (1997) The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 94 11031 PMID: 9380754
Giese et al (1983) Etomidate: a new intravenous anesthetic induction agent. Pharmacother. 3 251 PMID: 6359080
Moody et al (1998) Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABAA receptors. Toxicol.Lett. 100-101 209 PMID: 10049144
Keywords: Etomidate, supplier, GABA, mimetic, modulatory, agent, GABAA, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
