BiologicalActivity
Potentinhibitoroftransforminggrowthfactor-βtypeIreceptor(ALK5)(IC50valuesare18and93nMforALK5bindingandforTGF-βcellularassayrespectively).Inhibitsesophagealsquamouscellcarcinoma(ESCC)-inducedneoangiogenesis.Orallyactive.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
CompoundLibraries
GW788388isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 425.48 |
| Formula | C25H23N5O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 452342-67-5 |
| PubChemID | 10202642 |
| InChIKey | SAGZIBJAQGBRQA-UHFFFAOYSA-N |
| Smiles | O=C(NC5CCOCC5)C(C=C4)=CC=C4C1=CC(C2=CNN=C2C3=CC=CC=N3)=CC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.55 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight425.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.35mL | 11.75mL | 23.5mL |
| 5mM | 0.47mL | 2.35mL | 4.7mL |
| 10mM | 0.24mL | 1.18mL | 2.35mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |
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ProductDatasheets
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