Biological Activity
Selective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.
Technical Data
| M. Wt | 393.55 |
| Formula | C23H27N3OS |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 85951-63-9 |
| PubChem ID | 84008 |
| InChI Key | VDKBIFPJULZUPU-UHFFFAOYSA-N |
| Smiles | CCC(=O)N(C1CCN(CCC2=CC=C(C=C2)N=C=S)CC1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.94 | 10 | |
| ethanol | 39.35 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 393.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.7 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Rice et al (1983) Irreversible ligands with high selectivity toward δ or μ opiate receptors. Science 220 314 PMID: 6132444
Rothman et al (1985) Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides 6 227 PMID: 2991807
Schoffelmeer et al (1988) μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate. Eur.J.Pharmacol. 154 169 PMID: 2906610
Keywords: FIT, supplier, Irreversible, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, Fentanyl, isothiocyanate, Delta, Opioid, Receptors, Delta, Opioid, Receptors, Tocris Bioscience
