BiologicalActivity
PotentandselectiveinhibitorofclassIhistonedeacetylases(HDACs)(IC50valuesare36,47,510and14,000nMforHDAC1,HDAC2,HDAC4andHDAC6respectively).Exhibitscytotoxicityagainstvarioushumantumorcelllines;alsoexhibitsantitumoractivityagainsthumantumorxenografts.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofRomidepsinisreviewedontheChemicalProbeswebsite.
TechnicalData
| M.Wt | 540.7 |
| Formula | C24H36N4O6S2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 128517-07-7 |
| PubChemID | 5352062 |
| InChIKey | OHRURASPPZQGQM-GCCNXGTGSA-N |
| Smiles | O=C([C@H]([C@H](C)C)NC(/C(NC([C@@H]2NC([C@@H]([C@H](C)C)N1)=O)=O)=C/C)=O)O[C@H](/C=C/CCSSC2)CC1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.41 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight540.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.85mL | 9.25mL | 18.49mL |
| 5mM | 0.37mL | 1.85mL | 3.7mL |
| 10mM | 0.18mL | 0.92mL | 1.85mL |
| 50mM | 0.04mL | 0.18mL | 0.37mL |
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