Biological Activity
Potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.
Compound Libraries
FPL 64176 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 347.41 |
| Formula | C22H21NO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 120934-96-5 |
| PubChem ID | 3423 |
| InChI Key | MDMWHKZANMNXTF-UHFFFAOYSA-N |
| Smiles | COC(=O)C1=C(C)NC(C)=C1C(=O)C1=CC=CC=C1CC1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.37 | 50 | |
| ethanol | 8.69 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 347.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Baxter et al (1993) Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J.Med.Chem. 36 2739 PMID: 7692047
Rampe et al (1993) Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176. J.Pharmacol.Exp.Ther. 265 1125 PMID: 7685384
Zheng et al (1991) Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol.Pharmacol. 40 734 PMID: 1719369
Keywords: FPL 64176, supplier, Potent, activator, Ca2+, channels, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, FPL64176, Voltage-gated, Calcium, Channels, Voltage-gated, Calcium, Channels, Tocris Bioscience
