Biological Activity
Selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.
Technical Data
| M. Wt | 308.5 |
| Formula | C20H36O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 28399-31-7 |
| PubChem ID | 9904718 |
| InChI Key | CONYTTFKIUJZOF-UHFFFAOYSA-N |
| Smiles | CCCCCC(C2)C2CC1C(CCCCCCCC(O)=O)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.85 | 100 | |
| ethanol | 30.85 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 308.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.21 mL | 32.41 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.48 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Yamamoto et al (2005) The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130 207 PMID: 15561436
Kanno et al (2006) The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J.Lipid Res. 47 1146 PMID: 16520488
Tanaka and Nishizaki (2003) The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg.Med.Chem.Letts. 13 1037 PMID:
Keywords: FR 236924, supplier, pkc, pkce, epsilon, protein, kinase, c, a7, α7, alpha7, nAChR, nicotinic, acetylycholine, receptor, ACh, FR236924, DCP-LA, Protein, Kinase, C, Nicotinic, (a7), Receptors, Protein, Kinase, C, Tocris Bioscience
