Biological Activity
Selective D1-like dopamine receptor partial agonist (EC50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α2-adrenoceptor antagonist in vitro (Ki = 15 - 25 nM).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data
| M. Wt | 342.22 |
| Formula | C16H16ClNO3.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 181217-39-0 |
| PubChem ID | 21642479 |
| InChI Key | NLMPGIXLXSPNFS-UHFFFAOYSA-N |
| Smiles | Cl.OC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.58 | 100 | |
| water | 3.06 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 342.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.61 mL | 29.22 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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References
References are publications that support the products' biological activity.
Hahn et al (1982) Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist. J.Pharmacol.Exp.Ther. 223 305 PMID: 6127401
Nichols et al (1990) The pharmacology of fenoldopam. Am.J.Hypertens. 3 116S PMID: 1974439
Sibley et al (1982) Interactions of novel dopaminergic ligands with D-1 and D-2 dopamine receptors. Life Sci. 31 637 PMID: 6127585
Keywords: Fenoldopam hydrochloride, supplier, Selective, D1-like, partial, agonists, Dopamine, Receptors, D5, dopaminergic, SKF82526, GlaxoSmithKline, GSK, SKF, 82526, D1, and, D5, Receptors, D1, and, D5, Receptors, Tocris Bioscience
