Biological Activity
Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Technical Data
| M. Wt | 391.55 |
| Formula | C26H33NO2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 65646-68-6 |
| PubChem ID | 5288209 |
| InChI Key | AKJHMTWEGVYYSE-FXILSDISSA-N |
| Smiles | CC(/C=C/C1=C(C)CCCC1(C)C)=CC=CC(C)=CC(=O)NC1=CC=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.16 | 100 | |
| ethanol | 39.16 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 391.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.77 mL | 25.54 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Le Doze et al (2000) Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat. Drug Metab.Dispos. 28 205 PMID: 10640519
Takahashi (2000) Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide). Biol.Pharm.Bull. 23 222 PMID: 10706389
Ulukaya and Wood (1999) Fenretinide and its relation to cancer. Cancer Treat.Rev. 25 229 PMID: 10448131
Keywords: Fenretinide, supplier, Synthetic, retinoid, agonists, Potent, anti-cancer, agent, RXR, Retinoid, X, Receptors, RAR, RAMBA, Retinoic, Acid, 4-HPR, Retinoic, Acid, Receptors, Retinoid, X, Receptor, Retinoic, Acid, Receptors, Tocris Bioscience
