Biological Activity
Selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.
Compound Libraries
Fexofenadine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 538.12 |
| Formula | C32H39NO4.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 153439-40-8 |
| PubChem ID | 63002 |
| InChI Key | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
| Smiles | Cl.CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.9 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 538.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.86 mL | 9.29 mL | 18.58 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.72 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.86 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269 PMID: 9506246
Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76 PMID: 16037679
Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Eur.J.Pharmacol. 530 205 PMID: 16388798
Keywords: Fexofenadine hydrochloride, supplier, H1, receptor, antagonists, non-sedating, antiallergic, agent, Receptors, Histamine, histaminergic, MDL16455, MDL, 16455, Terfenidine, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience
