Biological Activity
Potent inhibitor of cyclooxygenase (IC50 values are 0.1 and 0.4 μM for inhibition of human COX-1 and COX-2 respectively). Analgesic, anti-inflammatory and antipyretic in vivo. Inhibits tumor cell growth in vitro and in vivo. Regulates prostate stem cell antigen through activation of Akt kinase. Also inhibits fibroblast proliferation in vitro.
Technical Data
| M. Wt | 244.26 |
| Formula | C15H13FO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 5104-49-4 |
| PubChem ID | 3394 |
| InChI Key | SYTBZMRGLBWNTM-UHFFFAOYSA-N |
| Smiles | CC(C(O)=O)C1=CC=C(C(F)=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 6.11 | 25 | |
| DMSO | 24.43 | 100 | |
| ethanol | 12.21 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 244.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.47 mL | 40.94 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.19 mL |
| 10 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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References
References are publications that support the products' biological activity.
Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479 PMID: 7832763
Glenn et al (1973) The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3 210 PMID: 4776365
Hoferova et al (2002) The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. Cancer Invest. 20 490 PMID: 12094544
Zemskova et al (2006) Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase. Biochem.Pharmacol. 72 1257 PMID: 16949054
Keywords: Flurbiprofen, supplier, Cyclooxygenase, inhibitors, inhibits, COX, Oxidase, Oxygenases, Oxidases, stem, cells, Akt, kinases, Analgesics, anti-inflammatory, and, antipyretics, Cyclooxygenase, Stem, Cell, Signaling, Cyclooxygenase, Tocris Bioscience
