Biological Activity
Selective μ opioid receptor antagonist.
Licensing Information
Sold with the permission of the University of Minnesota
Compound Libraries
β-Funaltrexamine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 490.99 |
| Formula | C25H30N2O6.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 72786-10-8 |
| PubChem ID | 44522395 |
| InChI Key | BIPHUOBUKMPSQR-NQGXHZAGSA-N |
| Smiles | OC1=C(O4)C([C@]([C@@H]4[C@@](NC(/C=C/C(OC)=O)=O)([H])CC3)5[C@]3(O)[C@H](N(CC6CC6)CC5)C2)=C2C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.1 | 100 | |
| water | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 490.99. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.18 mL | 20.37 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jiang et al (1990) μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice. J.Pharmacol.Exp.Ther. 252 1006 PMID: 2156986
Takemorei et al (1981) The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltrexone. Eur.J.Pharmacol. 70 445 PMID: 6263637
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