Biological Activity
Potent and selective PAR2 receptor agonist (pD2 = 7.0). Causes a dose-dependent relaxation of murine femoral arteries.
Technical Data
| M. Wt | 777.96 |
| Formula | C36H63N11O8 |
| Sequence |
LIGRLX (Modifications: Leu-1 = 2-Furoyl-Leu, X = Orn & C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 729589-58-6 |
| PubChem ID | 10395438 |
| InChI Key | OSKIRYSKGDEIOG-WTWMNNMUSA-N |
| Smiles | [H]N([C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(N)=O)C(=O)C1=CC=CO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 777.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.29 mL | 6.43 mL | 12.85 mL |
| 5 mM | 0.26 mL | 1.29 mL | 2.57 mL |
| 10 mM | 0.13 mL | 0.64 mL | 1.29 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
McGuire et al (2004) 2-Furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J.Pharmacol.Exp.Ther. 309 1124 PMID: 14976230
Alshurafa et al (2004) A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation. BMC Pharmacol. 4 12 PMID: 15265236
Olianas et al (2007) Proteinase-activated receptors 1 and 2 in rat olfactory system: layer-specific regulation of multiple signaling pathways in the main olfactory bulb and induction of neurite retraction in olfactory sensory neurons. Neuroscience 146 1289 PMID: 17434682
Keywords: 2-Furoyl-LIGRLO-amide, supplier, Potent, selective, PAR2, agonists, Receptors, Protease-Activated, proteinase-activated, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
