Biological Activity
FASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.
Technical Data
| M. Wt | 464.38 |
| Formula | C24H16O10 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1094451-90-7 |
| PubChem ID | 24896615 |
| InChI Key | KJCWIWDPTNVWRX-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC(O)=C(O)C(O)=C3)OC2=CC(OC(C4=CC(O)=C(O)C(O)=C4)=O)=CC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.44 | 100 | |
| ethanol | 46.44 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 464.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.77 mL | 21.53 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.31 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Puig et al (2011) A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 13 R131 PMID: 22177475
Puig et al (2009) Novel inhibitors of fatty acid synthase with anticancer activity. Clin.Cancer Res. 15 7608 PMID: 20008854
Keywords: G 28UCM, supplier, G28UCM, fatty, acid, synthase, inhibitors, inhibits, FASN, breast, cancer, Fatty, Acid, Synthase, Fatty, Acid, Synthase, Tocris Bioscience
